Molecular Biology belonging to the Vitamin D Radio

Molecular biology of the calciferol receptor (VDR) is a key factor in a great many processes which can be important for general homeostasis. VDRs are located in a variety of cellular material, including monocytes, dendritic cells, macrophages, neutrophils, keratinocytes, and epithelial cells.

The vitamin D receptor is a indivisible receptor that is activated by the calciferol hormone. It is a receptor that varieties a heterodimer with the retinoid X receptor. The binding of the vitamin D complex together with the RXR leads to the service of many intracellular signaling pathways. These pathways produce immediate answers independent of the transcriptional response of target family genes.

VDRs are usually thought to mediate the effects of calciferol on cuboid maintenance. This is maintained the correlation between bone fragments density and VDR receptor alleles in individuals. In addition , numerous VDR goal genes had been identified, including calcium-binding aminoacids, calbindin D-9k and 25-hydroxyvitamin D3 24-hydroxylase.

Many studies have investigated the word of VDR in various tissue. For instance, confocal microscopy indicates VDR indivisible staining in human bande cells. In addition , VDR has been recognized in white matter oligodendrocytes. These findings have generated the hypothesis that calcium-dependent platelet account activation may be regulated by fast non-genomic effects of VDR in mitochondria.

In addition to vitamin D, VDRs have been suggested as a factor in regulation of calcium homeostasis in the digestive tract. Yet , the exact device is not as yet known. Various factors, including environmental exposures and genetic factors, may regulate VDR appearance.

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